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The game is set between Mission: Impossible II and Mission: Impossible III. Players take on the role of Ethan Hunt on a mission to stop a dangerous virus called ICEWORM, developed by the terrorist-backed Surma Corporation. The threat? A computer virus capable of breaching any security system worldwide. Alongside familiar allies—Luther Stickell (voiced by Ving Rhames) and Billy Baird—Ethan is joined by new IMF members: disguise expert George Spelvin and FBI-trained agent Jasmine Curry. Together, they work to uncover and destroy Surma’s deadly plot.